Increasing the Dose of Smoking Cessation Treatments…
Increasing the Dose of Smoking Cessation Treatments Improved Abstinence After Initial Treatment Failure Cinciripini PM et al. Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine Replacement: A Randomized Clinical Trial. JAMA. Published online May 2, 2024. doi:10.1001/jama.2024.4183
https://jamanetwork.com/journals/jama/article-abstract/2818356
“Participants receiving varenicline or combination nicotine replacement therapy who were nonabstinent after 6 weeks were rerandomized to continue their medication, increase the dosage, or switch medications for another 6 weeks. Increasing the dosage led to the greatest benefit for those originally taking varenicline, whereas those receiving combined nicotine replacement therapy benefited similarly from the dosage increase and switching to varenicline, although secondary abstinence measures suggested that the dosage increase may provide longer-term benefit.”
Stephen Hamann
