Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine
Madison MC, Landers CT, Gu BH, Chang CY, Tung HY, You R, Hong MJ, Baghaei N, Song LZ, Porter P, Putluri N, Salas R, Gilbert BE, Levental I, Campen MJ, Corry DB, Kheradmand F. Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine. J Clin Invest. 2019 Sep 4. pii: 128531. doi: 10.1172/JCI128531.
“Researchers exposed mice to e-cigarette aerosol without and with nicotine and found that the aerosol altered lipid (fat) balance in the lungs in ways that depressed the ability of the lung macrophages to fight infections and disrupted normal production of surfactants, chemicals in lungs that help keep the air sacs from collapsing. This effect did not depend on the nicotine, but was related to the propylene glycol and vegetable glycerin that are the primary carriers in e-cigarettes.
The paper is technical, but worth reading because it points to the biological pathways that explain these effects. It adds to the growing case that e-cigs are not just cigarettes without as many harmful constituents, but also bring their own unique toxic effects.”
Explanation from Here
