Smoke exposure contributes to aggressive head and neck cancer
Domingo-Vidal, M. et al. (2019) Cigarette Smoke Induces Metabolic Reprogramming of the Tumor Stroma in Head and Neck Squamous Cell Carcinoma. Molecular Cancer Research. doi.org/10.1158/1541-7786.MCR-18-1191.
Researchers studying the effects of cigarette smoke on tumor progression showed that cigarette smoke reprograms the cells surrounding the cancer cells, and helps drive head and neck squamous-cell cancer aggressiveness.
Fibroblasts surround and support cancer growth. In a key finding, the researchers found a protein on tobacco-exposed fibroblasts, a major mechanism by which cigarette smoke exerts cancer aggressiveness.
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