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Divergence in Cigarette Discontinuation Rates by Use of Electronic Nicotine Delivery Systems (ENDS)

Kasza KA, et al. Divergence in Cigarette Discontinuation Rates by Use of Electronic Nicotine Delivery Systems (ENDS): Longitudinal Findings From the United States PATH Study Waves 1-6. Nicotine Tob Res. 2024 Apr 3:ntae027. doi: 10.1093/ntr/ntae027. Epub ahead of print. PMID: 38566367.

Authors found that “between 2018/19 and 2021, about 30% of smokers who also used e-cigarettes (dual users) stopped smoking cigarettes compared to 20% of smokers who did not use e-cigarettes.”

https://pubmed.ncbi.nlm.nih.gov/38566367/

“However, the 30% of smokers will continue to suffer the ongoing risks of e-cigarette use which have similar risks to cigarettes for some diseases and nearly as high a risk for others. (Glantz SA, et al. Population-based Disease Odds for E-cigarettes and Dual Use versus Cigarettes. NEJM Evidence. Feb 2024). In addition, before they stopped smoking, they were dual users of both cigarettes and e-cigarettes, which is more dangerous than just smoking. In contrast, the 20% of smokers who stopped smoking without using e-cigarettes are now nicotine-free and achieve rapid reductions in disease risk.”

“Kasza and colleagues’ result is broadly consistent with a meta-analysis of randomized controlled trials of e-cigarettes that found that smokers assigned to e-cigarettes were about half as likely (OR 0.50; 95% CI 0.32-0.77) to be nicotine-free at the end of the trial than those randomized to NRT (Hanewinkel R, et al. 2022).”

Stephen Hamann

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