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Bene-Alhasan Y. American Conference of Cardiology (ACC) Scientific Presentation. “Electronic Nicotine Product Use Is Associated with Incident Heart Failure – The All of Us Research Program,” presented at the ACC Annual Scientific Session, Atlanta, Georgia. 7 April 2024.

“Researchers used data from surveys and electronic health records in All of Us, a large national study of U.S. adults run by the National Institutes of Health, to analyze associations between e-cigarette use and new diagnoses of heart failure in 175,667 study participants (an average age of 52 years and 60.5% female). Of this sample, 3,242 participants developed heart failure within a median follow-up time of 45 months.

https://www.acc.org/About-ACC/Press-Releases/2024/04/01/21/51/study-links-e-cigarette-use-with-higher-risk-of-heart-failure

The results showed that people who used e-cigarettes at any point were 19% more likely to develop heart failure compared with people who had never used e-cigarettes. In calculating this difference, researchers accounted for a variety of demographic and socioeconomic factors, other heart disease risk factors and participants’ past and current use of other substances, including alcohol and tobacco products. The researchers also found no evidence that participants’ age, sex or smoking status modified the relationship between e-cigarettes and heart failure.

Researchers said that the study’s prospective observational design allows them to infer, but not conclusively determine, a causal relationship between e-cigarette use and heart failure. However, with its large sample size and detailed data on substance use and health information, Bene-Alhasan said the study is one of the most comprehensive studies to assess this relationship to date.”

Comment: Research keeps finding links between e-cigarettes and cardiovascular, respiratory, and neurological effects, exposing the myth that e-cigarettes are safe. Stephen Hamann