Variability in Constituents of E-Cigarette Products Containing Nicotine Analogues
Erythropel HC, et al. Variability in Constituents of E-Cigarette Products Containing Nicotine Analogues. JAMA. 2024;332(9):753–755. doi:10.1001/jama.2024.12408 “Although the Food and Drug Administration (FDA) is authorized to regulate tobacco products and nicotine content, this authority does not extend to chemical analogues of nicotine.1 The manufacturer of a recently introduced e-cigarette (Spree Bar [product 1]; Charlie’s Holdings) containing 5% 6-methylnicotine (6MN), a nicotine analogue with an added methyl group, claims it is exempt from FDA tobacco-product regulations, thereby allowing marketing with youth-appealing flavors and avoiding tobacco product taxes.” However, “In rodents, 6MN is more toxic and pharmacologically more potent than nicotine…”
https://jamanetwork.com/journals/jama/fullarticle/2822083
“Human pharmacologic and toxicologic data for nicotine analogues are lacking, raising concerns about their addictive potential and adverse effects. This study characterized and quantified constituents in both products to assess product consistency and inform future risk assessments.”
Stephen Hamann
