Yusuf O, Greenstreet C (April 22, 2025) Vaping-Associated Lung Injury With Suspected Diffuse Alveolar Haemorrhage (DAH): A Case Report. Cureus 17(4): e82799. doi:10.7759/cureus.82799

https://www.cureus.com/articles/320874-vaping-associated-lung-injury-with-suspected-diffuse-alveolar-haemorrhage-a-case-report#!/

“This case report describes a rare presentation of suspected DAH within the context of e-cigarette or vaping product use-associated lung injury (EVALI), a condition often manifesting as acute lung injury (ALI) with features like hypoxemia and bilateral infiltrates [4]. Since its recognition in 2019, EVALI has been increasingly diagnosed, with early case series reporting diverse presentations, including spontaneous pneumothorax, eosinophilic pneumonia, hypersensitivity pneumonitis, and rarely, pulmonary haemorrhage [4,5]. Notable cases of suspected DAH linked to vaping include severe haemoptysis requiring intensive care, often associated with herbal or plant-based vape products, though confirmed cases remain sparse [6,7]. The overlap between suspected DAH and ALI in EVALI underscores the disease’s heterogeneous pathology, necessitating careful diagnostic evaluation to distinguish specific patterns.”

Note: This technical clinical case report illustrates the continuing tragedy of acute lung injury (ALI) from e-cigarette use. Since worldwide surveillance is lacking, single cases must be collected to understand better all the factors that lead to positive interventions and treatments, given the diversity of case presentations. Of primary concern is the prevention of e-cigarette use that results in acute lung injury. Stephen Hamann

TRC Research Commentary

Han D, et al. Nicotine Pouch and E-Cigarette Use and Co-Use Among US Youths in 2023 and 2024. JAMA Netw Open. 30 Apr 2025;8(4):e256739. doi:10.1001/jamanetworkopen.2025.6739

https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2833331

“What are the prevalence of, cross-year changes in, and sociodemographic variables associated with self-reported nicotine pouch and e-cigarette use and co-use among US 10th and 12th graders in 2023 and 2024?

In this cross-sectional study of survey data on a nationally representative sample of 10 146 youths, nicotine pouch lifetime use (3.0% to 5.4%), use in the past 12 months (2.4% to 4.6%), and use in the past 30 days (1.3% to 2.6%) and nicotine pouch plus e-cigarette co-use significantly increased from 2023 to 2024. In contrast, e-cigarette use in the past 12 months declined. Pouch use was higher among 12th-grade, male, rural, and non-Hispanic White youths.

These findings suggest that US youth nicotine pouch use and dual use with e-cigarettes increased from 2023 to 2024, and surveillance, regulation, and prevention efforts addressing pediatric nicotine use are warranted.”

Comment: These US results illustrate how the tobacco industry steps up alternative addictive products (nicotine pouches) as controls are placed on other products (e-cigarettes) to maintain a ‘replacement population’ of youth addicts for future profits. Stephen Hamann