Impaired cellular function and inflammation from vaping
Tommasi S, Pabustan N, Li M, et al. A novel role for vaping in mitochondrial gene dysregulation and inflammation fundamental to disease development. Scientific Reports. 23 Nov 2021. Volume 11, Article number: 22773
https://www.nature.com/articles/s41598-021-01965-1#ref-CR6
Comparative analysis of the gene networks and canonical pathways dysregulated in vapers and smokers showed strikingly similar patterns in the two groups, although the extent of transcriptomic changes was more pronounced in smokers than in vapers. Of significance is the preferential targeting of mitochondrial genes in both vapers and smokers, concurrent with impaired functional networks, which drive mitochondrial DNA-related disorders. Equally significant is the dysregulation of immune response genes in vapers and smokers, modulated by upstream cytokines, including members of the interleukin and interferon family, which play a crucial role in inflammation.
Comment: Vaping causes gene dysregulation which affects disease development. Stephen Hamann
Stephen Hamann
