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Endothelial Function Impaired from 4 types of cigarettes, including e-cigarettes

Nabavizadeh P, Liu J, Rao P, et al. Impairment of Endothelial Function by Cigarette Smoke Is Not Caused by a Specific Smoke Constituent, but by Vagal Input From the Airway. Arteriosclerosis, Thrombosis, and Vascular Biology. 26 Oct 2022;42:1324–1332, “We investigated several smoke constituents that we hypothesized to mediate this effect by exposing rats and measuring arterial flow-mediated dilation (FMD) pre- and post-exposure. We measured FMD before and after inhalation of sidestream smoke from research cigarettes containing normal and reduced nicotine levels with and without menthol, as well as 2 of the main aldehyde gases found in both smoke and e-cigarette aerosol (acrolein and acetaldehyde) and inert carbon nanoparticles.
https://www.ahajournals.org/doi/10.1161/ATVBAHA.122.318051

FMD was reduced by all four kinds of research cigarettes, with the reduction ranging from 20% to 46% depending on the cigarette type.”

Authors conclude that “There is no single constituent or class of constituents responsible for acute impairment of endothelial function by smoke; rather, we propose that acute endothelial dysfunction by disparate inhaled products is caused by vagus nerve signaling initiated by airway irritation.”

S. Hamann

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