E-cigarette exposure disrupts antitumor immunity and promotes metastasis
Arias-Badia M, et al. (16 Aug 2024) E-cigarette exposure disrupts antitumor immunity and promotes metastasis. Front. Immunol. 15:1444020. doi: 10.3389/fimmu.2024.1444020.
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1444020/full
“In 2019 the FDA proposed adding 19 compounds to the HPHC list, including propylene glycol and glycerol, to reflect compounds in e-cigarettes (47). While e-cigarette components may induce lower carcinogenesis (although there is little data beyond lower biomarkers of exposure), there are many indirect effects that must be considered when assessing their health impact, including promotion of metastasis or immunosuppressive infiltration documented here. The results presented in this study underscore the consideration of propylene glycol as a harmful component, given its widespread use in e-cigarettes as well as heated tobacco products.
Our results demonstrate new potential risks associated with e-cigarettes. Future assessments of the safety of e-cigarettes should include not only incidence of cancer but also the acceleration of cancers caused by other agents.”
Comment: These results are significant given the common practice of dual use, where carcinogens from combustible tobacco may be accelerated through e-cigarette constituents like propylene glycol and glycerol. Stephen Hamann
